The former Good Day LA host, 46, and Grant Reynolds have two children together; daughter Ruby, 5, and son, Rocco, 3.
She said in a statement: 'It is with great regret that my marriage to Grant is ending after more than six years.
Over: Jillian Barberie has split from her husband Grant Reynolds, pictured here in 2009
'This was a mutual decision that was not taken lightly and we are committed to our children and will work together to ensure their happy and healthy upbringing.'
She later posted a message to fans on Twitter, saying: 'Thank you so much from the bottom of my heart. I'm devastated. Going to take some time out. Xx'
The pair wed in 2006 in an intimate backyard ceremony and at the time she described him as 'the love of my life'.
'Committed to our children': The couple have a son Rocco and daughter Ruby
The two appeared in reality show Househusbands of Hollywood, which ran for one season in 2009.
In September Jillian was axed from Good Day LA after almost 20 years on the show.
Dorothy Lucey was also sacked last year but Steve Edwards remains as anchor.